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戒烟新药：伐尼克兰片连载 (临床药理学)

Posted in : www.freemed.cn

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Mon, Jan 19 2009, 06:14

一、概述伐尼克兰片(Varenicline)含有活性成分伐尼克兰是乙酰胆碱受体a4β2 亚型的部分激动剂。伐尼克兰酒石酸盐是一种白色、微白到轻度黄色的固体，高度易溶于水。酒石酸伐尼克兰分子量361．35D，分子式C13 H13N3·C4H6O6。二、临床药理学 1．作用机制伐尼克兰与神经尼古丁乙酰胆碱受体α4 β2 亚型的结合具有高度亲和力和选择性。伐尼克兰对戒烟的疗效是伐尼克兰作用于乙酰胆碱受体亚型后发挥激动效应并同时阻断尼古丁与乙酰胆碱受体α4β2 亚型结合的结果。体外电生理研...

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戒烟新药：伐尼克兰片连载 (临床药理学)

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